BDBM289653 6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)methyl)-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5 (6H)-one::US10092575, Example 141::US10376514, Example 141

SMILES COc1ccc(Cn2c3sc4CN(CC5CCOCC5)CCc4c3c3ncnn3c2=O)c(F)c1

InChI Key InChIKey=FOZFBBKUKXGMND-UHFFFAOYSA-N

Data  14 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 289653   

TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50: <100nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  690nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of PDE4D3 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  7.90E+3nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  280nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE11A4 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE8A1 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE9A2 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human PDE7A1 (122-end residues) expressed in Baculovirus infected Sf9 insect cells assessed as decrea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  260nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE5A1 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity tested against human calpain 1 in Molt-4 cells (intact human T-cell leukemia cell line)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  26nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50: <100nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent