BDBM289689 8-(4-Chlorobenzoyl)-6-(3,4-dimethoxybenzyl)-8,9,10,11-tetrahydropyrido[3',2':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one::US10092575, Example 178::US10376514, Example 178

SMILES COc1ccc(Cn2c3sc4N(CCCc4c3c3ncnn3c2=O)C(=O)c2ccc(Cl)cc2)cc1OC

InChI Key InChIKey=APEZIQPMBZZQOG-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 289689   

TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM289689(8-(4-Chlorobenzoyl)-6-(3,4-dimethoxybenzyl)-8,9,10...)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM289689(8-(4-Chlorobenzoyl)-6-(3,4-dimethoxybenzyl)-8,9,10...)
Affinity DataIC50: >1.00E+4nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM289689(8-(4-Chlorobenzoyl)-6-(3,4-dimethoxybenzyl)-8,9,10...)
Affinity DataEC50: >1.00E+4nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent