BDBM289845 Methyl (4-((((S)-1-((R)-6-chloro-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,3′-pyrrolidin]-1′-yl)-1-oxo-3-phenylpropan-2-yl)amino)methyl)phenyl)carbamate::US10093683, Example 222

SMILES COC(=O)Nc1ccc(CN[C@@H](Cc2ccccc2)C(=O)N2CCC3(C2)OC(=O)Nc2ccc(Cl)cc32)cc1

InChI Key InChIKey=OHGXATBCNXRTFP-GMMLNUAGSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289845   

TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM289845(Methyl (4-((((S)-1-((R)-6-chloro-2-oxo-1,2-dihydro...)
Affinity DataKi:  8.75E+3nM ΔG°:  -6.90kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent