BDBM289847 (4R)-1′-((1-(3-amino-1H-indazol-6-yl)ethyl)-L-phenylalanyl)-6-chlorospiro[benzo[d][1,3]oxazine-4,3′-pyrrolidin]-2(1H)-one dihydrochloride::US10093683, Example 224

SMILES CC(N[C@@H](Cc1ccccc1)C(=O)N1CCC2(C1)OC(=O)Nc1ccc(Cl)cc21)c1ccc2c(N)n[nH]c2c1

InChI Key

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289847   

TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM289847((4R)-1′-((1-(3-amino-1H-indazol-6-yl)ethyl)-...)
Affinity DataKi:  8.75E+3nM ΔG°:  -6.90kcal/molepH: 7.4 T: 2°CAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent