BDBM289890 (S)-2-Hydroxy-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyrimidin-2-yloxy]-naphthalen-2- ylmethyl}-piperazin-1-yl)-propan-1-one::US9573957, Example 30

SMILES C[C@H](O)C(=O)N1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289890   

TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM289890((S)-2-Hydroxy-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyrimi...)
Affinity DataIC50:  1.30nMpH: 7.5 T: 2°CAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent