BDBM290020 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-quinolin-2-ylmethyl}- piperazine-1-carbonyl)- cyclobutanecarbonitrile::US9573957, Example 146

SMILES O=C(N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1)C1(CCC1)C#N

InChI Key InChIKey=QRPXJTLXLANVLU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 290020   

TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM290020(1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-qui...)
Affinity DataIC50:  3.40nMpH: 7.5 T: 2°CAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent