BDBM290051 US9573961, Example 36

SMILES Cc1c(ccc(Cl)c1C#N)[C@H]1CN2CCN(C[C@H]2CO1)C(=O)C1CCc2cc(ccc12)-n1cnnn1

InChI Key InChIKey=LJRJSOPYXIBOAN-PQSDXZOWSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 290051   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM290051(US9573961, Example 36)
Affinity DataIC50:  730nMpH: 7.4Assay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent