BDBM290185 US9573958, Compound 49

SMILES CC(C)C=C(C#N)C(=O)NCCn1c(NC(=O)c2ccc(s2)-c2cn[nH]c2)nc2ccccc12

InChI Key InChIKey=SUGHCDXVQDYDJM-LFIBNONCSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 290185   

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM290185(US9573958, Compound 49)
Affinity DataIC50:  5nMpH: 7.5Assay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent