BDBM290218 US9573958, Compound 125

SMILES CC(C)(CN1CCOCC1)C=C(C#N)C(=O)N1CCC[C@@H]1Cn1c(NC(=O)c2ccc(s2)C(F)F)nc2cc(CO)ccc12

InChI Key InChIKey=YIOJNOPENJTVBP-ONQWYEKWSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 290218   

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM290218(US9573958, Compound 125)
Affinity DataIC50:  770nMpH: 7.5Assay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent