BDBM291205 N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-methoxypiperidin-1-yl)quinoline-2-carboxamide::US9580418, Example 25::US9890162, Example 25

SMILES COC1CCN(CC1)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1

InChI Key InChIKey=GMOOBQVHKBXDSM-QUCCMNQESA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291205   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291205(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Affinity DataIC50: <10nMpH: 7.5 T: 2°CAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291205(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Affinity DataIC50: <100nMpH: 7.5 T: 2°CAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291205(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291205(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291205(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Affinity DataIC50: <100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291205(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Affinity DataIC50: <10nMpH: 7.5 T: 2°CAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent