BDBM291218 N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-7-(1-ethyl-1H-pyrazol-4-yl)-1,5-naphthyridine-2-carboxamide::US9580418, Example 38::US9890162, Example 38

SMILES CCn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@@H](N)[C@H](O)[C@H](C1)C1CC1

InChI Key InChIKey=CSYUITAHKPJRSS-XMERXJNXSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291218   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291218(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Affinity DataIC50: <10nMpH: 7.5 T: 2°CAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291218(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Affinity DataIC50: <100nMpH: 7.5 T: 2°CAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291218(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291218(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291218(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Affinity DataIC50: <100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291218(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Affinity DataIC50: <10nMpH: 7.5 T: 2°CAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent