BDBM291230 N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyridin-3-yl)-7-(4-hydroxypiperidin-1-yl)quinoline-2-carboxamide::US9580418, Example 50::US9890162, Example 50

SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(O)CC1

InChI Key InChIKey=IKHMRQXUEJYEEV-MJGOQNOKSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291230   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291230(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Affinity DataIC50: <10nMpH: 7.5 T: 2°CAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291230(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Affinity DataIC50: <100nMpH: 7.5 T: 2°CAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291230(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291230(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291230(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Affinity DataIC50: <100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 uL reactions were run in white 384 well polystyrene plates dotted with 0.8 uL compound/DMSO in the assay buffer (50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM291230(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Affinity DataIC50: <10nMpH: 7.5 T: 2°CAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent