BDBM291281 US9580432, Example 12

SMILES Nc1ncnc2n(nc(C(=O)Nc3nc4cc(F)ccc4o3)c12)[C@@H]1CCCN(C1)C(=O)C=C

InChI Key InChIKey=XCTFFUYIMFTLML-GFCCVEGCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 291281   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM291281(US9580432, Example 12)
Affinity DataIC50:  84.2nMpH: 7.5 T: 2°CAssay Description:With regard to the setting of the conditions for a method for measuring the inhibitory activity of a compound against EGFR kinase activity in vitro, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM291281(US9580432, Example 12)
Affinity DataIC50:  0.433nMpH: 7.5Assay Description:With regard to the setting of the conditions for a method for measuring the inhibitory activity of a compound against BTK kinase activity in vitro, i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent