BDBM291502 (E)-1-(6-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)oxy)-2-azaspiro[3.3]heptan-2-yl)-4-(3-fluoroazetidin-1-yl)but-2-en-1-one ::US10413562, Compound A222::US9580449, Example A222

SMILES Nc1ncnc(OC2CC3(C2)CN(C3)C(=O)\C=C\CN2CC(F)C2)c1-c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=WDCBEBXFHMPOCL-QPJJXVBHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 291502   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM291502((E)-1-(6-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-...)
Affinity DataIC50: <100nMAssay Description:2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC-AHA-EEPL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM291502((E)-1-(6-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-...)
Affinity DataIC50: <100nMpH: 7.5 T: 2°CAssay Description:The following describes a microfluidic, off-chip mobility shift kinase assay used to measure inherent potency of compounds against BTK enzyme. Compou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent