BDBM293358 US10106508, Compound I-27::US10106508, Example 27 N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-5-isopropoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinazolin-10-amine (I-27)

SMILES CC(C)Oc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c2OCCOc12

InChI Key InChIKey=FLDVQQIVLMTMPN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 293358   

TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM293358(US10106508, Compound I-27 | US10106508, Example 27...)
Affinity DataIC50: <1.00E+3nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM293358(US10106508, Compound I-27 | US10106508, Example 27...)
Affinity DataIC50: <200nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent