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BDBM293961 US10106552, Compound 36

SMILES: CC1CC(C)(C)Cc2nc3sc(C(N)=O)c(N)c3c(-c3cncs3)c12

InChI Key: InChIKey=AEANDRHTNFGZFP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 293961   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293961
PNG
(US10106552, Compound 36)
Show SMILES CC1CC(C)(C)Cc2nc3sc(C(N)=O)c(N)c3c(-c3cncs3)c12
Show InChI InChI=1S/C18H20N4OS2/c1-8-4-18(2,3)5-9-11(8)12(10-6-21-7-24-10)13-14(19)15(16(20)23)25-17(13)22-9/h6-8H,4-5,19H2,1-3H3,(H2,20,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 400n/an/an/an/an/an/a



Longevica Pharmaceuticals, Inc.

US Patent


Assay Description
To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...


US Patent US10106552 (2018)

More data for this
Ligand-Target Pair