BDBM294014 (2S)-5-(2-(4-((3-(4-(2- Methoxyethoxy)-2- methylphenyl)-2- methylbenzo[b]thiophen-5- yl)methoxy)phenyl)pent-3-yn-1- yl)-1H-tetrazole::US10106553, Compound 46

SMILES COCCOc1ccc(-c2c(C)sc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1

InChI Key

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 294014   

TargetFree fatty acid receptor 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294014((2S)-5-(2-(4-((3-(4-(2- Methoxyethoxy)-2- methylph...)
Affinity DataEC50:  47nMT: 2°CAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanocortin receptor 4(Rattus norvegicus)TBA
LigandPNGBDBM294014((2S)-5-(2-(4-((3-(4-(2- Methoxyethoxy)-2- methylph...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294014((2S)-5-(2-(4-((3-(4-(2- Methoxyethoxy)-2- methylph...)
Affinity DataEC50:  47nMAssay Description:Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed