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BDBM294718 US10112899, Example 195

SMILES: COc1c(F)cccc1C(=O)N1Cc2c(C1)c(C)c(-c1cc(F)c3OCCCc3c1C)c([C@H](OC(C)(C)C)C(O)=O)c2C

InChI Key: InChIKey=VVLUWGQDEIDFMG-HKBQPEDESA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 294718   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Human immunodeficiency virus type 1 integrase


(Human immunodeficiency virus 1)
BDBM294718
PNG
(US10112899, Example 195)
Show SMILES COc1c(F)cccc1C(=O)N1Cc2c(C1)c(C)c(-c1cc(F)c3OCCCc3c1C)c([C@H](OC(C)(C)C)C(O)=O)c2C
Show InChI InChI=1S/C34H37F2NO6/c1-17-20-11-9-13-42-30(20)26(36)14-22(17)27-18(2)23-15-37(32(38)21-10-8-12-25(35)29(21)41-7)16-24(23)19(3)28(27)31(33(39)40)43-34(4,5)6/h8,10,12,14,31H,9,11,13,15-16H2,1-7H3,(H,39,40)/t31-/m0/s1
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MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



ViiV HEALTHCARE UK LIMITED

US Patent


Assay Description
Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...


US Patent US10112899 (2018)

More data for this
Ligand-Target Pair