BDBM295042 3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-N-(3-hydroxy-3-methyl-butyl)-4-methyl-benzenesulfonamide hydrochloride::US10112926, Example 5

SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O

InChI Key InChIKey=BGNRHJBZCKJOLD-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 295042   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM295042(3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyri...)
Affinity DataIC50:  80nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295042(3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyri...)
Affinity DataIC50:  1.15E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM295042(3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyri...)
Affinity DataIC50: >9.55E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM295042(3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyri...)
Affinity DataIC50:  6.50E+3nMpH: 7.5Assay Description:Binding Assays are based on the binding and displacement of an Alexa Fluor 647-labeled, ATP-competitive kinase inhibitors to the kinase of interest. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295042(3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyri...)
Affinity DataIC50:  11nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295042(3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyri...)
Affinity DataIC50:  60nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM295042(3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyri...)
Affinity DataIC50:  4.90E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent