BDBM296038 4-(2-methoxy-4-{2-[3-(1H- pyrazol-5-yl)phenyl] pyrrolidine-1-carbonyl} phenyl)-1H-pyrazole::US10112939, Example 77

SMILES COc1cc(ccc1-c1cn[nH]c1)C(=O)N1CCCC1c1cccc(c1)-c1ccn[nH]1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 296038   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM296038(4-(2-methoxy-4-{2-[3-(1H- pyrazol-5-yl)phenyl] pyr...)
Affinity DataIC50:  887nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent