BDBM29701 Pyridoimidazolone, 5a

SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)cc2)ccc1Cl

InChI Key InChIKey=MBDHTDOTFOZBKB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 29701   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
The Institute Of Cancer Research

LigandPNGBDBM29701(Pyridoimidazolone, 5a)
Affinity DataIC50:  23nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM29701(Pyridoimidazolone, 5a)
Affinity DataIC50:  23nMAssay Description:Inhibition of BRAF V600E mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM29701(Pyridoimidazolone, 5a)
Affinity DataIC50:  2.39E+3nMAssay Description:Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed