BDBM297336 5-((9H-purin-6-yl)amino)isoindolin-1-one (Cpd. No. 1F)::US10112955, Example 1

SMILES O=C1NCc2cc(Nc3ncnc4[nH]cnc34)ccc12

InChI Key InChIKey=ZVKNCTZBEXAHCH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 297336   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM297336(5-((9H-purin-6-yl)amino)isoindolin-1-one (Cpd. No....)
Affinity DataIC50:  23nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM297336(5-((9H-purin-6-yl)amino)isoindolin-1-one (Cpd. No....)
Affinity DataIC50:  550nMAssay Description:Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent