BDBM297342 3-methyl-5-(pyrimidin-4-ylamino)isoindolin-1-one (Cpd. No. 8)::US10112955, Example 8

SMILES CC1NC(=O)c2ccc(Nc3ccncn3)cc12

InChI Key InChIKey=OWEDOBFUVPKBNA-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 297342   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Effector Therapeutics

US Patent
LigandPNGBDBM297342(3-methyl-5-(pyrimidin-4-ylamino)isoindolin-1-one (...)
Affinity DataIC50:  550nMAssay Description:Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Effector Therapeutics

US Patent
LigandPNGBDBM297342(3-methyl-5-(pyrimidin-4-ylamino)isoindolin-1-one (...)
Affinity DataIC50:  550nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Effector Therapeutics

US Patent
LigandPNGBDBM297342(3-methyl-5-(pyrimidin-4-ylamino)isoindolin-1-one (...)
Affinity DataIC50:  28nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM297342(3-methyl-5-(pyrimidin-4-ylamino)isoindolin-1-one (...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Effector Therapeutics

US Patent
LigandPNGBDBM297342(3-methyl-5-(pyrimidin-4-ylamino)isoindolin-1-one (...)
Affinity DataIC50:  45nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB