BindingDB logo
myBDB logout

BDBM297738 (R)-1-(isoindolin-2-yl)-3-(3-(1-methyl-1H-benzo[d]imidazol-6-yl)phenoxy)propan-2-ol::US10118918, Compound 17::US9732072, Compound 17

SMILES: Cn1cnc2ccc(cc12)-c1cccc(OC[C@H](O)CN2Cc3ccccc3C2)c1

InChI Key: InChIKey=WQQGWPMSSVHIRU-JOCHJYFZSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 297738   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297738
PNG
((R)-1-(isoindolin-2-yl)-3-(3-(1-methyl-1H-benzo[d]...)
Show SMILES Cn1cnc2ccc(cc12)-c1cccc(OC[C@H](O)CN2Cc3ccccc3C2)c1
Show InChI InChI=1S/C25H25N3O2/c1-27-17-26-24-10-9-19(12-25(24)27)18-7-4-8-23(11-18)30-16-22(29)15-28-13-20-5-2-3-6-21(20)14-28/h2-12,17,22,29H,13-16H2,1H3/t22-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
General Materials.S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), bicine, KCl, Tween20, dimethylsulfoxide (DMSO), bovine skin gelatin (BSG)...


US Patent US9732072 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297738
PNG
((R)-1-(isoindolin-2-yl)-3-(3-(1-methyl-1H-benzo[d]...)
Show SMILES Cn1cnc2ccc(cc12)-c1cccc(OC[C@H](O)CN2Cc3ccccc3C2)c1
Show InChI InChI=1S/C25H25N3O2/c1-27-17-26-24-10-9-19(12-25(24)27)18-7-4-8-23(11-18)30-16-22(29)15-28-13-20-5-2-3-6-21(20)14-28/h2-12,17,22,29H,13-16H2,1H3/t22-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair