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BDBM297751 US10118918, Compound 30

SMILES: O[C@@H](CNC(=O)c1ccnc(NC2CCOCC2)c1)CN1Cc2ccccc2C1

InChI Key: InChIKey=BUVYNFIPZCVEHV-FQEVSTJZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 297751   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM297751
PNG
(US10118918, Compound 30)
Show SMILES O[C@@H](CNC(=O)c1ccnc(NC2CCOCC2)c1)CN1Cc2ccccc2C1
Show InChI InChI=1S/C22H28N4O3/c27-20(15-26-13-17-3-1-2-4-18(17)14-26)12-24-22(28)16-5-8-23-21(11-16)25-19-6-9-29-10-7-19/h1-5,8,11,19-20,27H,6-7,9-10,12-15H2,(H,23,25)(H,24,28)/t20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Epizyme, Inc.

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....


US Patent US10118918 (2018)

More data for this
Ligand-Target Pair