BDBM298477 US10125101, Example 27

SMILES CNC(=O)c1cc(C)c(c(C)c1)-c1ccc(F)c2[C@@H](CCc12)Nc1ccc(nc1)[C@H]1C[C@@H]1C(O)=O

InChI Key InChIKey=UWYJLJXDKKINEA-AWRGLXIESA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 298477   

TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM298477(US10125101, Example 27)
Affinity DataEC50:  148nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM298477(US10125101, Example 27)
Affinity DataEC50:  148nMAssay Description:Agonist activity at human GPR40 expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM298477(US10125101, Example 27)
Affinity DataIC50: >5.00E+4nMAssay Description:The inhibition of cytochrome P450 2C9-isoenzyme catalyzed hydroxylation of diclofenac by the test compound is assayed at 37° C. with human liver micr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C8(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM298477(US10125101, Example 27)
Affinity DataIC50: >5.00E+4nMAssay Description:The inhibition of cytochrome P450 2C8-isoenzyme catalyzed deethylation of amodiaquine by the test compound is assayed at 37° C. with human liver micr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent