BDBM299151 (6S,8R)-6-(5-(2- (3-(fluoromethyl) azetidin-1- yl)ethoxy) pyridin-2-yl)-7- isobutyl-8- methyl-6,7,8,9- tetrahydro-3H- pyrazolo[4,3- f]isoquinoline::US10125135, Example 40
SMILES CC(C)CN1[C@H](C)Cc2c(ccc3[nH]ncc23)[C@H]1c1ccc(OCCN2CC(CF)C2)cn1
InChI Key
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 299151
Affinity DataIC50: 9.40nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of fluormone ES2 green reagent from human GST-tagged ERalpha LBD (282 to 595 residues) expressed in baculovirus infected insect cells in...More data for this Ligand-Target Pair
Affinity DataIC50: 0.398nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair