BDBM299398 N-[3-(4-amino- quinazolin-6-yl)- 5-fluoro-phenyl]- 2-pyrrolidin-1- yl-acetamide::US9592235, Example 191::US9855269, Compound 37

SMILES Nc1ncnc2ccc(cc12)-c1cc(F)cc(NC(=O)CN2CCCC2)c1

InChI Key InChIKey=GDCGMGVDMXRLGC-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299398   

TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM299398(N-[3-(4-amino- quinazolin-6-yl)- 5-fluoro-phenyl]-...)
Affinity DataIC50:  58.6nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM299398(N-[3-(4-amino- quinazolin-6-yl)- 5-fluoro-phenyl]-...)
Affinity DataIC50:  58.6nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB