BDBM299582 6-(3-chloro- phenoxy) pyrido[3,2-d] pyrimidin- 4-amine::US9592235, Example 352::US9855269, Compound 248

SMILES Nc1ncnc2ccc(Oc3cccc(Cl)c3)nc12

InChI Key InChIKey=ZLSPQBPEHAKXPQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299582   

TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM299582(6-(3-chloro- phenoxy) pyrido[3,2-d] pyrimidin- 4-a...)
Affinity DataIC50:  145nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM299582(6-(3-chloro- phenoxy) pyrido[3,2-d] pyrimidin- 4-a...)
Affinity DataIC50:  145nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent