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BDBM300258 US9593110, 18-3

SMILES: Cc1cnc(o1)C(=O)N[C@@H](C[C@@H](N)C(O)=O)Cc1ccc(cc1Cl)-c1cc(Cl)ccc1F

InChI Key: InChIKey=LAAXTGVUVLNARM-DNVCBOLYSA-N

Data: 1 KI

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300258   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neprilysin


(Homo sapiens (Human))
BDBM300258
PNG
(US9593110, 18-3)
Show SMILES Cc1cnc(o1)C(=O)N[C@@H](C[C@@H](N)C(O)=O)Cc1ccc(cc1Cl)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C22H20Cl2FN3O4/c1-11-10-27-21(32-11)20(29)28-15(9-19(26)22(30)31)6-13-3-2-12(7-17(13)24)16-8-14(23)4-5-18(16)25/h2-5,7-8,10,15,19H,6,9,26H2,1H3,(H,28,29)(H,30,31)/t15-,19-/m1/s1
PDB

KEGG

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PC cid
PC sid
UniChem
US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair