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BDBM300339 US9593110, 41

SMILES: NCCC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cnn[nH]1)C(O)=O

InChI Key: InChIKey=OMRHZIVDJMGZRH-VQIMIIECSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300339   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neprilysin


(Homo sapiens (Human))
BDBM300339
PNG
(US9593110, 41)
Show SMILES NCCC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cnn[nH]1)C(O)=O
Show InChI InChI=1S/C23H24ClFN6O4/c24-15-5-6-18(25)17(10-15)14-3-1-13(2-4-14)9-16(28-22(33)20-12-27-31-30-20)11-19(23(34)35)29-21(32)7-8-26/h1-6,10,12,16,19H,7-9,11,26H2,(H,28,33)(H,29,32)(H,34,35)(H,27,30,31)/t16-,19-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem
US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair