BDBM300427 US10130622, Example 00006
SMILES COCCS(=O)(=O)NC(=O)c1cc(N2CCC(CC2)OC)c2c(nn(-c3ccccc3)c2n1)C1CCC1
InChI Key InChIKey=PPNWCONNYOQLSG-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 300427
TargetCystic fibrosis transmembrane conductance regulator [G550E](Homo sapiens (Human))
Abbvie S.á.R.L.
US Patent
Abbvie S.á.R.L.
US Patent
Affinity DataIC50: 417nMAssay Description:YFP-Halide Influx Assay for the CFTR-ΔF508 Mutation and Suppressor mutants (I539T or G550E)The YFP halide influx assay measures the functionalit...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Abbvie S.á.R.L.
US Patent
Abbvie S.á.R.L.
US Patent
Affinity DataIC50: 104nMAssay Description:For this purpose, HEK293 cells are transfected with plasmid DNA containing WT CFTR and seeded in 96 well plates (70,000 HEK cells/well). Two days aft...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Abbvie S.á.R.L.
US Patent
Abbvie S.á.R.L.
US Patent
Affinity DataIC50: >6.67E+3nMAssay Description:For this purpose, HEK293 cells are transfected with plasmid DNA containing WT CFTR and seeded in 96 well plates (70,000 HEK cells/well). Two days aft...More data for this Ligand-Target Pair