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BDBM300757 US10130642, Example 6-17

SMILES: CC(CO)(CC(Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cc(O)n[nH]1)C(O)=O

InChI Key: InChIKey=MEAGGUKEVLEGMQ-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300757   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neprilysin


(Homo sapiens (Human))
BDBM300757
PNG
(US10130642, Example 6-17)
Show SMILES CC(CO)(CC(Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cc(O)n[nH]1)C(O)=O
Show InChI InChI=1S/C23H25N3O5/c1-23(14-27,22(30)31)13-18(24-21(29)19-12-20(28)26-25-19)11-15-7-9-17(10-8-15)16-5-3-2-4-6-16/h2-10,12,18,27H,11,13-14H2,1H3,(H,24,29)(H,30,31)(H2,25,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
3.55n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US10130642 (2018)

More data for this
Ligand-Target Pair