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BDBM301033 4-[5-(2-cyclopropylethynyl)-2-{[(3S)- pyrrolidin-3- ylmethyl]amino}pyrimidin-4- yl]benzonitrile::US10131664, Example 26

SMILES: N#Cc1ccc(cc1)-c1nc(NC[C@H]2CCNC2)ncc1C#CC1CC1

InChI Key: InChIKey=SVPNKQAIOZSQML-KRWDZBQOSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 301033   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301033
PNG
(4-[5-(2-cyclopropylethynyl)-2-{[(3S)- pyrrolidin-3...)
Show SMILES N#Cc1ccc(cc1)-c1nc(NC[C@H]2CCNC2)ncc1C#CC1CC1
Show InChI InChI=1S/C21H21N5/c22-11-16-4-6-18(7-5-16)20-19(8-3-15-1-2-15)14-25-21(26-20)24-13-17-9-10-23-12-17/h4-7,14-15,17,23H,1-2,9-10,12-13H2,(H,24,25,26)/t17-/m0/s1
PDB
MMDB

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KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair