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BDBM301037 4-[5-(4-methylphenyl)-2-[(piperidin-4- yl)amino]pyrimidin-4-yl]benzonitrile::US10131664, Example 30

SMILES: Cc1ccc(cc1)-c1cnc(NC2CCNCC2)nc1-c1ccc(cc1)C#N

InChI Key: InChIKey=WZPIFTGJDNFAHM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 301037   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301037
PNG
(4-[5-(4-methylphenyl)-2-[(piperidin-4- yl)amino]py...)
Show SMILES Cc1ccc(cc1)-c1cnc(NC2CCNCC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H23N5/c1-16-2-6-18(7-3-16)21-15-26-23(27-20-10-12-25-13-11-20)28-22(21)19-8-4-17(14-24)5-9-19/h2-9,15,20,25H,10-13H2,1H3,(H,26,27,28)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair