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BDBM301116 2-fluoro-4-[5-(2-methylindazol-5-yl)- 2-piperazin-1-ylpyrimidin-4- yl]benzonitrile::US10131664, Example 109

SMILES: Cn1cc2cc(ccc2n1)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCNCC1

InChI Key: InChIKey=QPBAZTFKTODRDF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 301116   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301116
PNG
(2-fluoro-4-[5-(2-methylindazol-5-yl)- 2-piperazin-...)
Show SMILES Cn1cc2cc(ccc2n1)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCNCC1
Show InChI InChI=1S/C23H20FN7/c1-30-14-18-10-15(4-5-21(18)29-30)19-13-27-23(31-8-6-26-7-9-31)28-22(19)16-2-3-17(12-25)20(24)11-16/h2-5,10-11,13-14,26H,6-9H2,1H3
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MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)

More data for this
Ligand-Target Pair