BDBM301457 7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl]propyl}-5-(4-methoxypyrimidin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,enantiomer 1::US10131670, Example 65

SMILES CC[C@H](c1cn(nn1)-c1ccccc1F)c1cc(-c2cncnc2OC)c2c(N)ncnn12

InChI Key InChIKey=PYBSRNIDUZXEBU-CYBMUJFWSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 301457   

TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301457(7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl]pro...)
Affinity DataEC50:  14nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301457(7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl]pro...)
Affinity DataEC50:  10.4nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent