BDBM30152 alpha-sulfone piperidine hydroxamate, 11l

SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)C2(CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C(=O)NO)c2ccccc2n1

InChI Key InChIKey=AAVVXYJNWGIBPT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 30152   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM30152(alpha-sulfone piperidine hydroxamate, 11l)
Affinity DataIC50:  65nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM30152(alpha-sulfone piperidine hydroxamate, 11l)
Affinity DataIC50:  80nMT: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM30152(alpha-sulfone piperidine hydroxamate, 11l)
Affinity DataIC50:  145nMT: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed