BDBM302246 US9598415, 158
SMILES CCS(=O)(=O)c1ccc(CNc2nc3cnc(nc3n([C@@H](C)C3CC3)c2=O)-c2c(C)ncnc2C2CC2)cn1
InChI Key InChIKey=RVQZJKYXPOLRGT-INIZCTEOSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 302246
Affinity DataIC50: 106nMAssay Description:A nuclear receptor transactivation assay is performed to quantitate the ability of test compounds to inhibit RORγ transactivation of a luciferas...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as reduction in channel tail current by whole cell patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Antagonist activity at RORgamma in human PBMC assessed as reduction in anti-CD3/IL-23 stimulated IL-17 level measured after 3 days by MSD assayMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Antagonist activity at GAL4 DBD-fused human RORgamma LBD expressed in pGL4.3 luc2P/GAL4UAS/hygro and pBIND transfected HEK293 cells assessed as inhib...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Antagonist activity at RORgamma in human whole blood derived CD4-positive T cells assessed as inhibition of IL-17 secretion from differentiated Th17 ...More data for this Ligand-Target Pair