BDBM303133 US10137122, Compound 5

SMILES Cc1[nH]nc2NC3=C(C(c4cccs4)c12)C(=O)CC(C)(C)C3

InChI Key

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 303133   

TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM303133(US10137122, Compound 5)
Affinity DataIC50:  550nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCasein kinase I isoform delta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM303133(US10137122, Compound 5)
Affinity DataKd:  550nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM303133(US10137122, Compound 5)
Affinity DataKd:  550nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM303133(US10137122, Compound 5)
Affinity DataIC50:  550nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In DepthDetails US Patent