BDBM303600 BDBM303601::US10138229, Example 112::US10875852, Example 113

SMILES NC(=O)c1c(N)n(nc1-c1ccc(OC2CC2)cc1)C1CC2(C1)CN(C2)C(=O)C=C

InChI Key InChIKey=ORXYAVDYXKZIFK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 303600   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM303600(BDBM303601 | US10138229, Example 112 | US10875852,...)
Affinity DataIC50:  6.70nMAssay Description:TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM303600(BDBM303601 | US10138229, Example 112 | US10875852,...)
Affinity DataIC50:  4.30nMAssay Description:An HTRF assay (Cisbio KinEASE-TK cat #62TK0PEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM303600(BDBM303601 | US10138229, Example 112 | US10875852,...)
Affinity DataIC50:  6.70nMAssay Description:An HTRF assay (Cisbio KinEASE-TK cat #62TK0PEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM303600(BDBM303601 | US10138229, Example 112 | US10875852,...)
Affinity DataIC50:  4.30nMAssay Description:TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent