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BDBM304275 US10143746, Example 1405

SMILES: CCCC[C@@H]1N(C)C(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC(=O)CNC(=O)[C@H](CSCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N3CCCC3C(=O)N[C@@H](Cc3cnc[nH]3)C(=O)N[C@@H](CC(C)C)C(=O)NC2)NC(=O)[C@H](C)NC1=O

InChI Key: InChIKey=JBHYZWWXOFKFJI-AWPRUYRESA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 304275   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Human PD-L1-TVMV-His


(Homo sapiens (Human))
BDBM304275
PNG
(US10143746, Example 1405)
Show SMILES CCCC[C@@H]1N(C)C(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC(=O)CNC(=O)[C@H](CSCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N3CCCC3C(=O)N[C@@H](Cc3cnc[nH]3)C(=O)N[C@@H](CC(C)C)C(=O)NC2)NC(=O)[C@H](C)NC1=O
Show InChI InChI=1S/C89H123N21O19S/c1-10-12-25-70-84(124)98-50(5)76(116)106-69-46-130-47-75(115)99-65(35-52-28-30-57(112)31-29-52)86(126)107(7)51(6)77(117)103-67(39-73(90)113)88(128)110-33-19-27-71(110)85(125)102-64(38-56-43-91-48-97-56)82(122)101-62(34-49(3)4)79(119)95-40-53(20-18-32-92-74(114)44-96-80(69)120)78(118)100-63(36-54-41-93-60-23-16-14-21-58(54)60)81(121)105-68(45-111)83(123)104-66(37-55-42-94-61-24-17-15-22-59(55)61)87(127)109(9)72(26-13-11-2)89(129)108(70)8/h14-17,21-24,28-31,41-43,48-51,53,62-72,93-94,111-112H,10-13,18-20,25-27,32-40,44-47H2,1-9H3,(H2,90,113)(H,91,97)(H,92,114)(H,95,119)(H,96,120)(H,98,124)(H,99,115)(H,100,118)(H,101,122)(H,102,125)(H,103,117)(H,104,123)(H,105,121)(H,106,116)/t50-,51-,53+,62-,63-,64-,65-,66-,67-,68-,69-,70-,71?,72-/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Homogenous Time-Resolved Fluorescence (HTRF) Assays of Binding of Soluble PD-1 to Soluble PD-L1. Soluble PD-1 and soluble PD-L1 refers to proteins wi...


US Patent US10143746 (2018)

More data for this
Ligand-Target Pair