BDBM307607 ((2R,4R)-4-((4-Methoxypyridin-2- yl)amino)-2-methylpyrrolidin-1-yl)(2- propylphenyl)methanone::US10150751, Example 46

SMILES CCCc1ccccc1C(=O)N1C[C@@H](C[C@H]1C)Nc1ncccc1OC

InChI Key InChIKey=ISKVVMRVQDGCHD-NVXWUHKLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307607   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307607(((2R,4R)-4-((4-Methoxypyridin-2- yl)amino)-2-methy...)
Affinity DataIC50:  9.83E+3nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307607(((2R,4R)-4-((4-Methoxypyridin-2- yl)amino)-2-methy...)
Affinity DataIC50:  179nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent