BDBM308172 2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-9-(6-fluoropyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one::US9650377, Example 95-2

SMILES Fc1ccc(cn1)-c1cccc2C3=CC(=NCC(=O)N3CCc12)n1cnc(n1)C1CC1

InChI Key InChIKey=PINXLCBEVHYEIY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 308172   

TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM308172(2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-9-(6-fluor...)
Affinity DataIC50: >1.00E+4nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM308172(2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-9-(6-fluor...)
Affinity DataIC50:  11nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent