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BDBM309282 5-chloro-N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]pyrrolidin-3-yl}-4-(2,2,2-trifluoroethoxy)pyridin-2-amine::US9656955, Example 806

SMILES: Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(OCC(F)(F)F)c(Cl)cn2)[C@H](C1)c1ccc(F)cc1

InChI Key: InChIKey=HXFAWQJRPUXADU-WBVHZDCISA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 309282   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM309282
PNG
(5-chloro-N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methy...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(OCC(F)(F)F)c(Cl)cn2)[C@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C21H20ClF4N5O3S/c1-30-10-20(28-12-30)35(32,33)31-8-15(13-2-4-14(23)5-3-13)17(9-31)29-19-6-18(16(22)7-27-19)34-11-21(24,25)26/h2-7,10,12,15,17H,8-9,11H2,1H3,(H,27,29)/t15-,17+/m1/s1
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PC cid
PC sid
UniChem
Article
US Patent
<10n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...


US Patent US9656955 (2017)


Article DOI: 10.1021/jm050458h
BindingDB Entry DOI: 10.7270/Q2Z60R48
More data for this
Ligand-Target Pair