BDBM309802 (R)-3-(4-(4-cyano-1-cyclopentylpiperidin-4-yl)phenylamino)-5-(3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl)pyrazine-2-carboxamide::US9656988, Example 271

SMILES CN1CCN([C@@H]2CCCN(C2)c2cnc(C(N)=O)c(Nc3ccc(cc3)C3(CCN(CC3)C3CCCC3)C#N)n2)C1=O

InChI Key InChIKey=HAFULHYXIOMYIW-RUZDIDTESA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 309802   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309802((R)-3-(4-(4-cyano-1-cyclopentylpiperidin-4-yl)phen...)
Affinity DataIC50: <10nMAssay Description:Human Btk kinase (Genbank accession # NP_000052) was purified from insect cells as a full-length construct containing a N-terminal 6×-His tag. Btk ki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309802((R)-3-(4-(4-cyano-1-cyclopentylpiperidin-4-yl)phen...)
Affinity DataIC50: <10nMAssay Description:Human Btk kinase (Genbank accession # NP_000052) was purified from insect cells as a full-length construct containing a N-terminal 6×-His tag. Btk ki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309802((R)-3-(4-(4-cyano-1-cyclopentylpiperidin-4-yl)phen...)
Affinity DataIC50:  55nMAssay Description:The degree of inhibition of a panel of kinases is determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309802((R)-3-(4-(4-cyano-1-cyclopentylpiperidin-4-yl)phen...)
Affinity DataIC50:  55nMAssay Description:The degree of inhibition of a panel of kinases is determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309802((R)-3-(4-(4-cyano-1-cyclopentylpiperidin-4-yl)phen...)
Affinity DataIC50: <10nMAssay Description:The degree of inhibition of a panel of kinases is determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent