BDBM309830 (R)-3-(4-(1-cyclopentylpiperidin-4-yl)phenylamino)-5-(3-(cyclopropanecarboxamido)piperidin-1-yl)pyrazine-2-carboxamide::US9656988, Example 299

SMILES NC(=O)c1ncc(nc1Nc1ccc(cc1)C1CCN(CC1)C1CCCC1)N1CCC[C@H](C1)NC(=O)C1CC1

InChI Key InChIKey=AYPQJCUSHCNNTD-XMMPIXPASA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 309830   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309830((R)-3-(4-(1-cyclopentylpiperidin-4-yl)phenylamino)...)
Affinity DataIC50: <10nMAssay Description:Human Btk kinase (Genbank accession # NP_000052) was purified from insect cells as a full-length construct containing a N-terminal 6×-His tag. Btk ki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309830((R)-3-(4-(1-cyclopentylpiperidin-4-yl)phenylamino)...)
Affinity DataIC50: <10nMAssay Description:Human Btk kinase (Genbank accession # NP_000052) was purified from insect cells as a full-length construct containing a N-terminal 6×-His tag. Btk ki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309830((R)-3-(4-(1-cyclopentylpiperidin-4-yl)phenylamino)...)
Affinity DataIC50:  55nMAssay Description:The degree of inhibition of a panel of kinases is determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309830((R)-3-(4-(1-cyclopentylpiperidin-4-yl)phenylamino)...)
Affinity DataIC50:  5.50E+3nMAssay Description:The degree of inhibition of a panel of kinases is determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309830((R)-3-(4-(1-cyclopentylpiperidin-4-yl)phenylamino)...)
Affinity DataIC50:  550nMAssay Description:The degree of inhibition of a panel of kinases is determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM309830((R)-3-(4-(1-cyclopentylpiperidin-4-yl)phenylamino)...)
Affinity DataIC50: <10nMAssay Description:The degree of inhibition of a panel of kinases is determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent