BDBM310739 US10150764, Compound 1
SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(Cl)cc(C(=O)NCc2c(CCN(C)C)cc3CCNn3c2=O)c1C
InChI Key InChIKey=NXEUEGIKIYTDQR-RQNOJGIXSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 310739
Affinity DataIC50: 75nMAssay Description:The assays were performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG, 100 mM KCl and 0.002% Tween20, prepared on the day...More data for this Ligand-Target Pair
Affinity DataIC50: 750nMAssay Description:Inhibition of wild-type EZH2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of EZH2 (unknown origin) assessed as reduction in H3K27me3 levelMore data for this Ligand-Target Pair
Affinity DataIC50: 149nMAssay Description:The assays were performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG, 100 mM KCl and 0.002% Tween20, prepared on the day...More data for this Ligand-Target Pair