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BDBM310875 8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-3,3a-dihydropyrrolo[1,2-a]quinoxaline-1,4(2H,5H)-dione::US10150767, Example 9

SMILES: Cn1cc(-c2ccc3NC(=O)C4CCC(=O)N4c3c2)c2cc[nH]c2c1=O

InChI Key: InChIKey=PLXSXLYLHZAVJA-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 310875   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD4 BD1 (aa 42-168)


(Homo sapiens (Human))
BDBM310875
PNG
(8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyr...)
Show SMILES Cn1cc(-c2ccc3NC(=O)C4CCC(=O)N4c3c2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C19H16N4O3/c1-22-9-12(11-6-7-20-17(11)19(22)26)10-2-3-13-15(8-10)23-14(18(25)21-13)4-5-16(23)24/h2-3,6-9,14,20H,4-5H2,1H3,(H,21,25)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 310n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair