BindingDB logo
myBDB logout

BDBM310877 4-methyl-7-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one::US10150767, Example 13

SMILES: CC1CC(=O)Nc2ccc(cc2N1)-c1cn(C)c(=O)c2[nH]ccc12

InChI Key: InChIKey=NEDMXFRJPRRUOE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 310877   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD4 BD1 (aa 42-168)


(Homo sapiens (Human))
BDBM310877
PNG
(4-methyl-7-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridi...)
Show SMILES CC1CC(=O)Nc2ccc(cc2N1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C18H18N4O2/c1-10-7-16(23)21-14-4-3-11(8-15(14)20-10)13-9-22(2)18(24)17-12(13)5-6-19-17/h3-6,8-10,19-20H,7H2,1-2H3,(H,21,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 170n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair